Serial oparty na motywach kultowego filmu przedstawia przygody dalmatyńczyków – Dolly i Dylana, ich rodziców, Delilah i Douga, oraz ich 97 braci i sióstr we współczesnym Londynie.
Dylan left with all the housework to do, wishes for a human "Pet" to do his chores for him./Dolly runs away from Home on Boom Night, now Dylan must set out to look for her, but also overcome his fears of Boom Night.
Dolly and Dylan clash over Puppy-Sitting Styles, so call a snap election to decide who shall be Top Dog, only for Diesel, the most unsuitable leader, to win.
After Dolly teases Dylan for being too domestic, Dylan is determined to show her he can be wild and enlists Fergus the Fox to bring out his inner wolf.
Dylan is Petrified when Dolly's best friend Roxy, the Rottweiler, reveals to him that she has a crush on him./Dolly spends the day with Doug at the fire station, but is disappointed with the boring mood there.
Dolly takes credit for writing Dylan's poems, in an attempt to impress Hansel. However, this then gets her invited to recite at a Poetry Slam. Shall Dolly still try to claim credit for the Poem, or shall she tell the truth?
When Delilah and Dolly have a falling out, on Mother's Day, Doug suggests that they should spend the day together at the Dog Spa, to help bring them Closer together. But, could this be a recipe for disaster?
There's a crime in the park and the evidence points to 101 Dalmatian Street, so Dylan turns detective. After a crime in the park, Dylan thinks he can handle the investigation alone, refusing help from his little bro Diesel who has super sniffing skills.
When Clarissa challenges Dolly to pass as posh at the Petiquette Pooch Cup, she takes things too far, goes makeover mad, gets human'ed up and almost forgets what matters most in the process./There's a flea outbreak at 101 Dalmatian Street. Dylan springs into action by forcing the infected in to quarantine. But the source of the infestation turns out to be quite the surprise.
When Clarissa tries to hog the royal visit to Camden Town, Dolly's 'revolution' causes chaos and puts poor Pearl in a pickle in the process. The Royal Corgis are not amused./It's payback time, Dolly and Dawkins set know-it-all Dylan up to believe that aliens have landed in Camden and that he is the only one who stands between doggy-kind and imminent annihilation.