Former iCarly sidekick Sam Puckett teams up with Hollywood Arts High School student Cat Valentine to take over Cat's grandmother's babysitting service.
Cat discovers Sam is really fast at texting and convinces her to compete in a texting competition against a sweet boy, Butler, who has an overbearing mom. Dice tries to avoid an annoying old friend.
When a babysitting client says, "You're my favorite babysitter ever", Sam and Cat debate which one of them he meant. They compete for their new clients' affection to see who really is the best babysitter.
When Sam and Cat agree to babysit Goomer while Dice goes away, they misapply Goomer's medication which causes him to temporarily lose his eyesight before a big match.
A competing babysitting service is posting fake, bad reviews about Sam and Cat's babysitting service. Sam and Cat confront their new competition and discover they're not what they appear to be.
Goomer's mom is coming to visit but has no idea that her son is an MMA fighter. Dice enlists the help of Sam and Cat to help convince Goomer's mom that Goomer is a high school teacher.
To boost their babysitting business, Sam and Cat make a commercial that features Dice's beloved dog. A family recognizes the dog and seeks legal ownership, claiming the dog belongs to them.
British con artists Gwen and Ruby return and, while pretending to be friendly, drive a wedge between Sam and Cat. When Sam and Cat catch on to this, they turn the tables on Gwen and Ruby.
Sam, Dice and Goomer go to an MMA fight and leave Cat home to study. Upon returning, they discover that Sam's motorcycle is missing and Cat can't remember the day. The group sets out to solve the mystery and get Sam's bike back.
Sam opens a safe in her bedroom and discovers a tunnel that leads to a secret room. Cat films herself for 24 hours so that her future self can watch it 10-years from now.
Sam and Cat's babysitting skills are tested when they look after a young boy, Oscar, who is very prone to accidents. The girls are determined to showing Oscar a fun time while struggling to keep him out of harm's way.
On Halloween, Sam and Cat are hired to babysit a doll, with unusual and creepy results. Cat also thinks she may have accidentally turned Dice into a monkey with a magic spell.
When ordered to rename their babysitting business because it's too similar to "Salmon Cat," a TV show from the seventies, Sam & Cat must track down the show's creators and resolve a years' long feud.
In order to prove she is clever, Cat plays a trick on Sam using a pair of twins that they are babysitting. Sam turns to her own twin, Melanie, to play a trick on Cat.
Sam and Cat are charged with getting a babysitting client to give up her "Poober" -- her ratty old stuffed animal. This proves much more difficult than it first appears.
When Sam eats all of the moon meatballs Cat prepared for a Special Moon Dinner, Cat has to make more. Cat gets distracted when she finds a shoe and becomes obsessed with finding its matching pair.
Sam notices that Cat has been spending lots of money. When she asks where it's coming from, Cat takes Sam to a "Magic ATM" that gives her free money. Sam worries that this might not be legal.
Cat's friend Jade comes to L.A. and Sam became friends with her. Cat invites Sam's old friend (and ex-boyfriend) to L.A. and things turn out so weird. Meanwhile, Dice gets a lot of tuna and it goes weird too.
Cat invents a holiday, "Yay Day", which is just an excuse to buy presents for everyone. When Cat snoops what other people have gotten her, she discovers an insulting present from Sam.
Sam and Cat notice everyone, including their friends, are becoming obsessed with a new phone game, "Brain Crush." The game distracts the audience at Cat's one woman show.
Sam & Cat must find a way to enjoy their favorite drink after it's been banned from California. But once they manage to have as much of it as possible and share it with everyone else, they find the authorities are searching for the seller.