The quads must try to behave for two days and resist opening a mysterious present, but quickly find out how badly things can go if they do not follow the rules.
When Dawn and Mae have a falling out, Dawn forbids Nicky, Ricky and Dicky from going to an upcoming concert with her, but the boys have other plans in mind.
The Quads' eavesdropping threatens to ruin their annual boys vs. girls scare night camp out because of a misunderstanding about going through the change.
When The Quads kidnap a rival soccer team's pig mascot as a prank, they have to pass it off as Anne's surprise birthday present to avoid being caught forgetting her birthday.
When Ricky is put in charge of school news production, he lets the power go into his head. However, when the rest of the Harper quadruplets realize why he's doing it, they come together to help him.
The Harper quads get detention, forcing them to miss the school carnival and the only way for them to make it to the carnival before it ends, is if they work with some of the bad kids.
The Quads accidentally force out the easygoing gym teacher, ruining the class for everyone; they think they've fixed everything with the perfect substitutes, but soon realize their parents have made things worse.
The Harper quads declare their own independence when Dawn decides to get her ears pierced and her brothers decide to get a snake as a pet without asking for permission from their parents.
The quads want to pull off a big stunt so that their class will be remembered by future students, but when they find out that the personal legacy they are leaving behind is not great, they have to fix both before it is too late.
The quads try to take the perfect picture at their Aunt Jackie's farm to best their rival quadruplets, the Kramdens, but end up hurting their aunt's chances to win a contest in the process.
When a famous theater director comes to town for auditions of The Wizard Of Oz, the quads know they were born to play these parts. But when Dawn doesn't get the part of Dorothy right away, she's on a mission to prove she is way better at acting then a diva theater star.